FBXL18, F-box and leucine rich repeat protein 18

FBXL18, F-box and leucine rich repeat protein 18

• The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]

• Gene Synonyms (F-box/LRR-repeat protein 18, Fbl18,)
• NCBI Gene ID: 80028
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DH63
  UNIPROT ID#>>A0A024R857
  UNIPROT ID#>>Q96D16
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

F-box and leucine rich repeat protein 18 interacts with:

• acyl-CoA synthetase family member 3
  F-box and leucine rich repeat protein 16
  keratin 40
  keratin associated protein 10-3
  keratin associated protein 4-12
  LY6/PLAUR domain containing 4
  notch 2 N-terminal like A
  transducin beta like 1 Y-linked
  ubiquitin like with PHD and ring finger domains 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.