TSEN2, tRNA splicing endonuclease subunit 2

TSEN2, tRNA splicing endonuclease subunit 2

• This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]

• Gene Synonyms (tRNA-splicing endonuclease subunit Sen2, TSEN2 tRNA splicing endonuclease subunit, hsSen2, tRNA-intron endonuclease Sen2, PCH2B, SEN2, SEN2L,)
• NCBI Gene ID: 80746
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NCE0
  UNIPROT ID#>>A0A024R2H2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tRNA splicing endonuclease subunit 2 interacts with:

• caseinolytic mitochondrial matrix peptidase chaperone subunit B
  CLP1, cleavage and polyadenylation factor I subunit
  GA binding protein transcription factor subunit beta 2
  LEO1 homolog, Paf1/RNA polymerase II complex component
  retbindin
  TEPSIN adaptor related protein complex 4 accessory protein
  transmembrane p24 trafficking protein family member 8
  tRNA splicing endonuclease subunit 15
  tRNA splicing endonuclease subunit 54
  tubulin beta 2B class IIb
  zinc and ring finger 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.