LMNB2, lamin B2

LMNB2, lamin B2

• This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]

• Gene Synonyms (lamin-B2, epididymis secretory sperm binding protein, lamin B3, EPM9, LAMB2, LMN2,)
• NCBI Gene ID: 84823
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q03252
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lamin B2 interacts with:

• angiomotin
  coiled-coil domain containing 120
  coiled-coil domain containing 88B
  G protein-coupled receptor associated sorting protein 2
  lamin B2
  LEO1 homolog, Paf1/RNA polymerase II complex component
  testis specific 10 interacting protein
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.