DEGS1, delta 4-desaturase, sphingolipid 1

DEGS1, delta 4-desaturase, sphingolipid 1

• This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]

• Gene Synonyms (sphingolipid delta(4)-desaturase DES1, cell migration-inducing gene 15 protein, degenerative spermatocyte homolog 1, lipid desaturase, degenerative spermatocyte homolog, lipid desaturase, dihydroceramide desaturase 1, membrane fatty acid (lipid) desaturase, membrane lipid desaturase, migration-inducing gene 15 protein, sphingolipid delta 4 desaturase, sphingolipid delta(4)-desaturase 1, DEGS, DEGS-1, DES1, Des-1, FADS7, HLD18, MIG15, MLD,)
• NCBI Gene ID: 8560
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R3P1
  UNIPROT ID#>>O15121
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

delta 4-desaturase, sphingolipid 1 interacts with:

• chromosome 4 open reading frame 3
  complexin 2
  cysteine and histidine rich 1
  eukaryotic translation initiation factor 5B
  HDGF like 2
  large 60S subunit nuclear export GTPase 1
  lysophosphatidic acid receptor 6
  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  natural killer cell cytotoxicity receptor 3 ligand 1
  proton activated chloride channel 1
  scavenger receptor class A member 3
  semaphorin 4G
  sirtuin 2
  solute carrier family 17 member 2
  tectonic family member 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.