B4GALT2, beta-1,4-galactosyltransferase 2

B4GALT2, beta-1,4-galactosyltransferase 2

• This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

• Gene Synonyms (beta-1,4-galactosyltransferase 2, N-acetyllactosamine synthase, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2, beta-1,4-GalTase 2, beta-4-GalT2, beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, lactose synthase A protein, nal synthase, B4Gal-T2, B4Gal-T3, beta4Gal-T2,)
• NCBI Gene ID: 8704
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60909
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

beta-1,4-galactosyltransferase 2 interacts with:

• prefoldin subunit 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.