B3GALNT1, beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

B3GALNT1, beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

• This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. [provided by RefSeq, Mar 2017]

• Gene Synonyms (UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1, P antigen synthase, P blood group globoside, UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 (Globoside blood group), UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypeptide 1 (Globoside blood group), UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase, b3Gal-T3, beta-1,3-GalNAc-T1, beta-1,3-GalTase 3, beta-1,3-galactosyltransferase 3, beta-3-Gx-T3, brainiac1, galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase, globoside synthase, globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, B3GALT3, GLCT3, GLOB, Gb4Cer, P, P1, beta3Gal-T3, galT3,)
• NCBI Gene ID: 8706
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7L9G8
  UNIPROT ID#>>B3KTQ4
  UNIPROT ID#>>O75752
  UNIPROT ID#>>Q49AT3
  UNIPROT ID#>>Q8TDY1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) interacts with:

• arachidonate lipoxygenase 3
  aspartic peptidase retroviral like 1
  carboxypeptidase A4
  chondroitin sulfate N-acetylgalactosaminyltransferase 2
  desmoglein 4
  dual specificity phosphatase 14
  FAM3 metabolism regulating signaling molecule C
  keratinocyte proline rich protein
  leucine rich repeat containing 15
  neuromedin U
  plakophilin 3
  ribonuclease A family member 7
  S100 calcium binding protein A14
  selenium binding protein 1
  zymogen granule protein 16B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.