PAPSS2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2

PAPSS2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2

• Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2, 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2, ATP sulfurylase/APS kinase 2, ATP sulfurylase/adenosine 5'-phosphosulfate kinase, PAPS synthase 2, PAPS synthetase 2, SK 2, adenosine 5'-phosphosulfate kinase, adenylyl-sulfate kinase, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2, epididymis secretory sperm binding protein, sulfate adenylyltransferase, ATPSK2, BCYM4, SK2,)
• NCBI Gene ID: 9060
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5TB52
  UNIPROT ID#>>O95340
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

3'-phosphoadenosine 5'-phosphosulfate synthase 2 interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  3'-phosphoadenosine 5'-phosphosulfate synthase 1
  anterior gradient 2, protein disulphide isomerase family member
  ariadne RBR E3 ubiquitin protein ligase 2
  centrosomal protein 19
  elongation factor Tu GTP binding domain containing 2
  G1 to S phase transition 2
  general transcription factor IIIC subunit 4
  heat shock transcription factor 2 binding protein
  potassium channel tetramerization domain containing 10
  RIC8 guanine nucleotide exchange factor A
  testis expressed 101
  WD repeat domain 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.