CBFA2T2, CBFA2/RUNX1 partner transcriptional co-repressor 2

CBFA2T2, CBFA2/RUNX1 partner transcriptional co-repressor 2

• In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (protein CBFA2T2, CBFA2/RUNX1 translocation partner 2, ETO homolog on chromosome 20, ETO homologous on chromosome 20, MTG8-like protein, MTG8-related protein 1, core-binding factor, runt domain, alpha subunit 2; translocated to, 2, myeloid translocation gene-related protein 1, myeloid translocation-related protein 1, EHT, MTGR1, ZMYND3, p85,)
• NCBI Gene ID: 9139
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43439
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CBFA2/RUNX1 partner transcriptional co-repressor 2 interacts with:

• ataxin 1 like
  BAG cochaperone 4
  CBFA2/RUNX1 partner transcriptional co-repressor 2
  centrosomal protein 83
  chromosome 16 open reading frame 70
  F-box and leucine rich repeat protein 19
  interferon regulatory factor 2 binding protein 2
  keratin associated protein 13-2
  N-terminal glutamine amidase 1
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  PR/SET domain 14
  PR/SET domain 6
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  SIN3 transcription regulator family member A
  sorbin and SH3 domain containing 3
  suppressor of IKBKE 1
  zinc finger C2HC-type containing 1A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.