PCSK7, proprotein convertase subtilisin/kexin type 7

PCSK7, proprotein convertase subtilisin/kexin type 7

• This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]

• Gene Synonyms (proprotein convertase subtilisin/kexin type 7, lymphoma proprotein convertase, prohormone convertase 7, prohormone convertase PC7, proprotein convertase 7, proprotein convertase 8, proprotein convertase PC7, proprotein convertase subtilisin/kexin type 7 precursor variant 2, subtilisin/kexin-like protease PC7, LPC, PC7, PC8, SPC7,)
• NCBI Gene ID: 9159
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16549
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proprotein convertase subtilisin/kexin type 7 interacts with:

• poly(A) binding protein cytoplasmic 1
  proprotein convertase subtilisin/kexin type 7
  synaptotagmin binding cytoplasmic RNA interacting protein

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