ASIC3, acid sensing ion channel subunit 3

ASIC3, acid sensing ion channel subunit 3

• This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

• Gene Synonyms (acid-sensing ion channel 3, acid sensing (proton gated) ion channel 3, amiloride-sensitive cation channel 3, testis, modulatory subunit of ASIC2a, neuronal amiloride-sensitive cation channel 3, proton-gated cation channel subunit, testis sodium channel 1, ACCN3, DRASIC, SLNAC1, TNaC1,)
• NCBI Gene ID: 9311
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHC3
  UNIPROT ID#>>A0A090N8Z6
  UNIPROT ID#>>A0A090N8Q1
  UNIPROT ID#>>A0A090N7X8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

acid sensing ion channel subunit 3 interacts with:

• acid sensing ion channel subunit 3
  golgi associated PDZ and coiled-coil motif containing
  lin-7 homolog B, crumbs cell polarity complex component
  PATJ crumbs cell polarity complex component

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.