MMP20, matrix metallopeptidase 20

MMP20, matrix metallopeptidase 20

• Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]

• Gene Synonyms (matrix metalloproteinase-20, enamel metalloproteinase, matrix metalloproteinase 20 (enamelysin), AI2A2, MMP-20,)
• NCBI Gene ID: 9313
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60882
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

matrix metallopeptidase 20 interacts with:

• diablo IAP-binding mitochondrial protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.