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DIABLO, diablo IAP-binding mitochondrial protein

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DIABLO, diablo IAP-binding mitochondrial protein

  • This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

  • Gene Synonyms (DFNA64, SMAC, diablo homolog, mitochondrial, diablo-like protein, direct IAP-binding protein with low pI, second mitochondria-derived activator of caspase,)
  • NCBI Gene ID: 56616
  • Species: Homo sapiens (Human)
  • UNIPROT ID#>>A0A0S2Z5U7
    UNIPROT ID#>>Q502X2
    UNIPROT ID#>>Q9NR28
    UNIPROT ID#>>K7X1S0
    UNIPROT ID#>>A0A0S2Z5P6
    UNIPROT ID#>>A0A024RBT2
  • View the NCBI Database for this Gene »

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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