RUBCN, rubicon autophagy regulator

RUBCN, rubicon autophagy regulator

• The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

• Gene Synonyms (run domain Beclin-1-interacting and cysteine-rich domain-containing protein, RUN and cysteine rich domain containing beclin 1 interacting protein, RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein, baron, beclin-1 associated RUN domain containing protein, rundataxin, KIAA0226, RUBICON, SCAR15,)
• NCBI Gene ID: 9711
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N4U6
  UNIPROT ID#>>Q92622
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

rubicon autophagy regulator interacts with:

• ankyrin repeat domain 11
  autophagy related 14
  bromodomain containing 1
  enkurin domain containing 1
  exocyst complex component 1
  exocyst complex component 2
  exocyst complex component 8
  FAM161 centrosomal protein A
  family with sequence similarity 9 member B
  NME/NM23 family member 7
  phosphoinositide-3-kinase regulatory subunit 4
  transcription elongation factor A N-terminal and central domain containing
  zinc finger protein 250
  zinc finger protein 648

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.