KCNA1, potassium voltage-gated channel subfamily A member 1

KCNA1, potassium voltage-gated channel subfamily A member 1

• This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]

• Gene Synonyms (AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1, potassium voltage-gated channel subfamily A member 1, potassium channel, voltage gated shaker related subfamily A, member 1, potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia), voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, voltage-gated potassium channel subunit Kv1.1,)
• NCBI Gene ID: 3736
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q09470
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

potassium voltage-gated channel subfamily A member 1 interacts with:

• apolipoprotein L2
  contactin associated protein 1
  dolichol kinase
  G protein-coupled receptor 152
  immediate early response 3 interacting protein 1
  jagunal homolog 1
  mal, T cell differentiation protein
  potassium channel regulator
  potassium voltage-gated channel subfamily A member 10
  potassium voltage-gated channel subfamily A member 2
  potassium voltage-gated channel subfamily A member 3
  potassium voltage-gated channel subfamily A member 4
  potassium voltage-gated channel subfamily E regulatory subunit 4
  protein kinase D2
  reticulon 4
  small glutamine rich tetratricopeptide repeat containing alpha
  transmembrane protein 14B
  transmembrane protein 86A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.