ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2

ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2

• Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

• Gene Synonyms (rho guanine nucleotide exchange factor 2, Rho/Rac guanine nucleotide exchange factor (GEF) 2, guanine nucleotide exchange factor H1, microtubule-regulated Rho-GEF, proliferating cell nucleolar antigen p40, GEF, GEF-H1, GEFH1, LFP40, Lfc, NEDMHM, P40,)
• NCBI Gene ID: 9181
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92974
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho/Rac guanine nucleotide exchange factor 2 interacts with:

• ankyrin repeat domain 28
  ankyrin repeat domain 28
  ankyrin repeat domain 52
  ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
  aurora kinase A interacting protein 1
  autophagy related 16 like 1
  Bet1 golgi vesicular membrane trafficking protein
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  calmodulin regulated spectrin associated protein 1
  calmodulin regulated spectrin associated protein family member 2
  centriolin
  centrosomal protein 170
  centrosomal protein 170B
  centrosomal protein 250
  cingulin
  coiled-coil domain containing 8
  COP9 signalosome subunit 7A
  cytoplasmic linker associated protein 1
  cytoskeleton associated protein 2
  doublecortin like kinase 1
  elongation factor Tu GTP binding domain containing 2
  F-box protein 6
  G2 and S-phase expressed 1
  kinesin family member 14
  kinesin family member C1
  kinesin light chain 2
  limb development membrane protein 1 like
  MAP7 domain containing 2
  MAP7 domain containing 3
  microtubule affinity regulating kinase 4
  microtubule associated protein 1S
  microtubule associated protein 9
  microtubule associated protein RP/EB family member 1
  microtubule associated scaffold protein 1
  MMS19 homolog, cytosolic iron-sulfur assembly component
  NEDD1 gamma-tubulin ring complex targeting factor
  NFKB inhibitor delta
  ninein
  nuclear RNA export factor 1
  p21 (RAC1) activated kinase 4
  p21 (RAC1) activated kinase 5
  PDZ domain containing 11
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing A5
  PR/SET domain 16
  proteasome activator subunit 3
  protein phosphatase 2, regulatory subunit A, alpha
  protein phosphatase 6 regulatory subunit 1
  protein phosphatase 6 regulatory subunit 2
  protein phosphatase 6 regulatory subunit 3
  protein phosphatase 6, catalytic subunit
  protein phosphatase 6, regulatory subunit 1
  RAD18 E3 ubiquitin protein ligase
  RAS related 2
  RecQ like helicase 4
  Rho/Rac guanine nucleotide exchange factor 2
  ribonuclease P/MRP subunit p25 like
  ring finger protein 31
  SNW domain containing 1
  sodium channel and clathrin linker 1
  spindle and kinetochore associated complex subunit 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin specific peptidase 21
  vir like m6A methyltransferase associated
  WD repeat domain 5
  WD repeat domain 83
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.