SLC9A3R1, SLC9A3 regulator 1

SLC9A3R1, SLC9A3 regulator 1

• This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]

• Gene Synonyms (Na(+)/H(+) exchange regulatory cofactor NHE-RF1, Na+/H+ exchange regulatory co-factor, ezrin-radixin-moesin binding phosphoprotein-50, regulatory cofactor of Na(+)/H(+) exchanger, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1, solute carrier family 9 isoform A3 regulatory factor 1, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1, EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2,)
• NCBI Gene ID: 9368
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14745
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SLC9A3 regulator 1 interacts with:

• A-kinase anchoring protein 10
  aminopeptidase puromycin sensitive
  amyloid beta precursor protein binding protein 2
  anterior gradient 2, protein disulphide isomerase family member
  ATP binding cassette subfamily C member 4
  carnosine dipeptidase 2
  cell division cycle associated 5
  DLG associated protein 4
  FTO alpha-ketoglutarate dependent dioxygenase
  guanine deaminase
  lactate dehydrogenase A like 6B
  N-acetylneuraminate synthase
  PALM2 and AKAP2 fusion
  PH domain and leucine rich repeat protein phosphatase 1
  PH domain and leucine rich repeat protein phosphatase 2
  phosphatase and tensin homolog
  phospholipase C beta 1
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  platelet derived growth factor receptor, beta polypeptide
  prenylcysteine oxidase 1
  protein phosphatase 4 regulatory subunit 3B
  protein phosphatase methylesterase 1
  protein tyrosine phosphatase receptor type Q
  radixin
  receptor for activated C kinase 1
  SLC9A3 regulator 1
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  solute carrier family 22 member 11
  solute carrier family 22 member 9
  solute carrier family 4 member 7
  solute carrier family 4 member 8
  solute carrier organic anion transporter family member 3A1
  TBC1 domain family member 10A
  transient receptor potential cation channel, subfamily C, member 4
  transient receptor potential cation channel, subfamily C, member 5
  triokinase and FMN cyclase
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin family domain containing 1
  vesicle associated membrane protein 5
  Yes1 associated transcriptional regulator
  zinc finger protein 468

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.