USP15, ubiquitin specific peptidase 15

USP15, ubiquitin specific peptidase 15

• This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

• Gene Synonyms (ubiquitin carboxyl-terminal hydrolase 15, deubiquitinating enzyme 15, ubiquitin thioesterase 15, ubiquitin thiolesterase 15, ubiquitin-specific-processing protease 15, UNPH-2, UNPH4,)
• NCBI Gene ID: 9958
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y4E8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin specific peptidase 15 interacts with:

• adhesion regulating molecule 1
  anaphase promoting complex subunit 1
  atlastin GTPase 3
  autophagy related 2B
  BICD cargo adaptor 2
  caspase recruitment domain family member 9
  cell division cycle 37, HSP90 cochaperone
  coiled-coil domain containing 57
  COP9 signalosome subunit 5
  COP9 signalosome subunit 7A
  COP9 signalosome subunit 7B
  cortactin binding protein 2
  CTTNBP2 N-terminal like
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 11A
  DDB1 and CUL4 associated factor 15
  DExD/H-box helicase 58
  DnaJ heat shock protein family (Hsp40) member C10
  dynamin 1 like
  egl-9 family hypoxia inducible factor 3
  epidermal growth factor receptor pathway substrate 15 like 1
  eukaryotic elongation factor 2 lysine methyltransferase
  family with sequence similarity 98 member A
  F-box protein 45
  fermitin family member 3
  gem nuclear organelle associated protein 4
  golgin A6 family member A
  GTPase activating protein and VPS9 domains 1
  HECT domain E3 ubiquitin protein ligase 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  high mobility group 20B
  influenza virus NS1A binding protein
  kinesin family member 15
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing 15
  leucine rich repeat kinase 2
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM8 homolog, U6 small nuclear RNA associated
  mediator complex subunit 4
  methylphosphate capping enzyme
  mindbomb E3 ubiquitin protein ligase 1
  MYC binding protein 2
  NOP53 ribosome biogenesis factor
  nuclear RNA export factor 1
  nucleolar and spindle associated protein 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  oxysterol binding protein like 3
  peptidylprolyl isomerase H
  PHD finger protein 7
  phosphatidylinositol 4-kinase type 2 alpha
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 31
  progesterone immunomodulatory binding factor 1
  prohibitin 2
  proteasome 26S subunit, non-ATPase 14
  protein phosphatase 4 regulatory subunit 2
  protein phosphatase 4 regulatory subunit 3A
  RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
  RANBP2-type and C3HC4-type zinc finger containing 1
  regulator of microtubule dynamics 3
  rhophilin Rho GTPase binding protein 1
  ring finger and CCCH-type domains 1
  ring finger protein 126
  ring finger protein 144B
  ring finger protein 19B
  ring finger protein 20
  ring finger protein 213
  ring finger protein 26
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA transcription, translation and transport factor
  serine/threonine kinase 33
  seryl-tRNA synthetase 2, mitochondrial
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  small glutamine rich tetratricopeptide repeat containing beta
  snurportin 1
  spindle apparatus coiled-coil protein 1
  SPRY domain containing 3
  STN1 subunit of CST complex
  stomatin like 2
  strawberry notch homolog 1
  striatin 3
  striatin 4
  striatin interacting protein 1
  SUMO peptidase family member, NEDD8 specific
  SUMO specific peptidase 3
  T-box brain transcription factor 1
  terminal uridylyl transferase 1, U6 snRNA-specific
  testis expressed 11
  transcription elongation factor A like 4
  transient receptor potential cation channel subfamily V member 5
  transmembrane protein 132A
  tripartite motif containing 11
  tripartite motif containing 17
  tripartite motif containing 46
  tripartite motif containing 5
  tripartite motif containing 54
  tripartite motif containing 63
  tripartite motif containing 74
  tubulin, gamma 1
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 S
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 20
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 28
  ubiquitin specific peptidase 32
  ubiquitin specific peptidase 33
  ubiquitin specific peptidase 51
  vir like m6A methyltransferase associated
  V-set and immunoglobulin domain containing 8
  WAPL cohesin release factor
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator
  YOD1 deubiquitinase
  zinc finger CCCH-type containing 13

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.