COPS5, COP9 signalosome subunit 5

COPS5, COP9 signalosome subunit 5

• The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CSN5, JAB1, MOV-34, SGN5, COP9 signalosome complex subunit 5, 38 kDa Mov34 homolog, COP9 constitutive photomorphogenic homolog subunit 5, jun activation domain-binding protein 1, signalosome subunit 5, testis secretory sperm-binding protein Li 231m,)
• NCBI Gene ID: 10987
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92905
  UNIPROT ID#>>A0A024R7W9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

COP9 signalosome subunit 5 interacts with:

• 5'-3' exoribonuclease 2
  actin beta like 2
  acyl-CoA synthetase bubblegum family member 2
  ADP ribosylation factor GTPase activating protein 1
  anaphase promoting complex subunit 13
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 7
  ankyrin repeat and BTB domain containing 2
  ankyrin repeat and SOCS box containing 6
  ankyrin repeat domain 12
  argonaute RISC catalytic component 2
  argonaute RISC component 1
  autophagy and beclin 1 regulator 1
  BCL2 like 14
  beta-secretase 1
  BRCA1/BRCA2-containing complex subunit 3
  bromodomain and WD repeat domain containing 1
  bromodomain containing 4
  BTB domain containing 1
  BTB domain containing 2
  BTB domain containing 9
  calmodulin like 5
  CaM kinase like vesicle associated
  caspase recruitment domain family member 11
  CD93 molecule
  cell cycle and apoptosis regulator 2
  centromere protein K
  centromere protein M
  centromere protein T
  centromere protein W
  cereblon
  chromatin licensing and DNA replication factor 1
  chromosome 7 open reading frame 50
  cilia and flagella associated protein 300
  cilia and flagella associated protein 58
  cleavage and polyadenylation specific factor 1
  CLOCK interacting pacemaker
  coiled-coil domain containing 47
  contactin 4
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  COP9 signalosome subunit 7A
  COP9 signalosome subunit 7B
  COP9 signalosome subunit 9
  copine 2
  copine 7
  cullin associated and neddylation dissociated 1
  cyclin D1 binding protein 1
  dachsous cadherin-related 2
  damage specific DNA binding protein 1
  DAZ associated protein 1
  DDB1 and CUL4 associated factor 11
  DDB1 and CUL4 associated factor 12
  DDB1 and CUL4 associated factor 16
  DDB1 and CUL4 associated factor 4
  DDB1 and CUL4 associated factor 4 like 1
  DDB1 and CUL4 associated factor 4 like 2
  DDB1 and CUL4 associated factor 8
  DEAD-box helicase 19B
  DEAD-box helicase 20
  DEAD-box helicase 56
  DEAH-box helicase 36
  defective in cullin neddylation 1 domain containing 1
  defensin beta 127
  denticleless E3 ubiquitin protein ligase
  denticleless E3 ubiquitin protein ligase homolog
  dermcidin
  DET1 and DDB1 associated 1
  DET1 partner of COP1 E3 ubiquitin ligase
  DExD-box helicase 52
  DExH-box helicase 29
  DExH-box helicase 30
  DExH-box helicase 57
  DLG associated protein 3
  DnaJ heat shock protein family (Hsp40) member C10
  DnaJ heat shock protein family (Hsp40) member C9
  dynein axonemal heavy chain 2
  EH domain binding protein 1
  elaC ribonuclease Z 2
  endothelial cell surface expressed chemotaxis and apoptosis regulator
  ERBB receptor feedback inhibitor 1
  factor interacting with PAPOLA and CPSF1
  family with sequence similarity 83 member H
  family with sequence similarity 98 member A
  family with sequence similarity 98 member B
  F-box and leucine rich repeat protein 14
  F-box and leucine rich repeat protein 18
  F-box and leucine rich repeat protein 5
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 9
  F-box protein 10
  F-box protein 11
  F-box protein 17
  F-box protein 21
  F-box protein 22
  F-box protein 3
  F-box protein 31
  F-box protein 44
  F-box protein 46
  F-box protein 6
  F-box protein 7
  F-box protein 9
  fem-1 homolog C
  fibrillarin like 1
  fibronectin type III and ankyrin repeat domains 1
  fidgetin, microtubule severing factor
  filaggrin family member 2
  folliculin interacting protein 1
  FtsJ RNA 2'-O-methyltransferase 3
  G protein nucleolar 3
  GADD45G interacting protein 1
  galectin 7B
  glutamate rich WD repeat containing 1
  glutaminyl-peptide cyclotransferase
  GTP binding protein 3, mitochondrial
  GTP binding protein 4
  H4 clustered histone 15
  H4 histone 16
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C like 1
  heterogeneous nuclear ribonucleoprotein U like 1
  heterogeneous nuclear ribonucleoprotein U like 2
  hornerin
  hydroxysteroid 11-beta dehydrogenase 1 like
  hypoxia inducible factor 1, alpha subunit
  ISL LIM homeobox 2
  kelch like family member 10
  kelch like family member 12
  kelch like family member 13
  kelch like family member 15
  kelch like family member 18
  kelch like family member 22
  kelch like family member 23
  kelch like family member 24
  kelch like family member 26
  kelch like family member 36
  kelch like family member 42
  kelch like family member 8
  kelch like family member 9
  kelch repeat and BTB domain containing 4
  kelch repeat and BTB domain containing 6
  keratin 24
  keratin 6C
  keratin 71
  keratin 76
  keratin 78
  keratin 80
  kynurenine aminotransferase 3
  La ribonucleoprotein 1, translational regulator
  La ribonucleoprotein 4B
  leucine rich repeat containing 47
  leucine rich repeat protein 1
  leucine rich repeats and calponin homology domain containing 2
  lin-28 homolog B
  LSM12 homolog
  LUC7 like 2, pre-mRNA splicing factor
  LUC7 like 3 pre-mRNA splicing factor
  Ly1 antibody reactive
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  microtubule associated protein RP/EB family member 1
  MINDY lysine 48 deubiquitinase 3
  mitochondrial calcium uptake 2
  mitochondrial ribosomal protein L11
  mitochondrial ribosomal protein L15
  mitochondrial ribosomal protein L43
  mitochondrial ribosomal protein S11
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S23
  mitochondrial ribosomal protein S25
  mitochondrial ribosomal protein S27
  mitochondrial transcription rescue factor 1
  mitogen-activated protein kinase kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase kinase 5
  Mtr4 exosome RNA helicase
  MYG1 exonuclease
  myoneurin
  myosin light chain kinase family member 4
  myozenin 1
  NFKB repressing factor
  NOP16 nucleolar protein
  NOP2/Sun RNA methyltransferase 2
  nuclear FMR1 interacting protein 2
  nuclear protein 1, transcriptional regulator
  nuclear receptor binding protein 1
  nucleoporin 42
  nudix hydrolase 16 like 1
  pelota mRNA surveillance and ribosome rescue factor
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  PHD and ring finger domains 1
  phosphodiesterase 12
  phosphoribosyl pyrophosphate synthetase 1 like 1
  placenta associated 8
  pleckstrin homology domain interacting protein
  POF1B actin binding protein
  poly(A) binding protein cytoplasmic 1
  poly(U) binding splicing factor 60
  polypeptide N-acetylgalactosaminyltransferase 13
  potassium channel tetramerization domain containing 10
  potassium channel tetramerization domain containing 18
  potassium channel tetramerization domain containing 3
  potassium channel tetramerization domain containing 6
  pre-mRNA processing factor 19
  pre-mRNA processing factor 31
  pre-mRNA processing factor 39
  pre-mRNA processing factor 40 homolog A
  proteasome activator subunit 4
  protein phosphatase 1 regulatory subunit 15A
  protein tyrosine phosphatase mitochondrial 1
  PWP1 homolog, endonuclein
  RBMX like 2
  RCC1 and BTB domain containing protein 1
  ribosomal L1 domain containing 1
  ribosomal protein L10 like
  ribosomal protein L26 like 1
  ribosomal protein L35
  ribosomal RNA processing 12 homolog
  ribosomal RNA processing 15 homolog
  ring finger protein 138
  ring finger protein 139
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 42
  RNA guanine-7 methyltransferase activating subunit
  RNA transcription, translation and transport factor
  schlafen family member 12 like
  SEH1 like nucleoporin
  serine/arginine repetitive matrix 2
  SH3 and multiple ankyrin repeat domains 3
  SH3KBP1 binding protein 1
  shisa family member 5
  Sin3A associated protein 130
  sirtuin 7
  small nuclear ribonucleoprotein U5 subunit 200
  sorting nexin 9
  spermatid perinuclear RNA binding protein
  spindle and kinetochore associated complex subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  staufen double-stranded RNA binding protein 2
  SUMO specific peptidase 6
  tau tubulin kinase 2
  terminal uridylyl transferase 4
  tetratricopeptide repeat domain 5
  torsin 1A interacting protein 2
  transducin beta like 2
  transformer 2 alpha homolog
  transient receptor potential cation channel subfamily C member 4 associated protein
  transmembrane channel like 1
  trinucleotide repeat containing adaptor 6B
  tRNA methyltransferase 1 like
  tRNA methyltransferase 61A
  tubulin alpha 1c
  tubulin beta 1 class VI
  tubulin beta class I
  tubulointerstitial nephritis antigen like 1
  U2 small nuclear RNA auxiliary factor 2
  U2 snRNP associated SURP domain containing
  unc-80 homolog, NALCN channel complex subunit
  UPF3B regulator of nonsense mediated mRNA decay
  vir like m6A methyltransferase associated
  WD repeat domain 5
  WD repeat domain 61
  WD repeat domain, phosphoinositide interacting 2
  WNK lysine deficient protein kinase 1
  YAE1 maturation factor of ABCE1
  yippee like 5
  YTH domain containing 2
  zinc finger CCCH-type containing, antiviral 1
  zinc finger protein 302
  zinc finger protein 554
  zinc finger RNA binding protein
  zyg-11 family member B, cell cycle regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.