FRS3, fibroblast growth factor receptor substrate 3

FRS3, fibroblast growth factor receptor substrate 3

• This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]

• Gene Synonyms (FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2, fibroblast growth factor receptor substrate 3, FGFR substrate 3, FGFR-signaling adaptor SNT2, suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor), testicular tissue protein Li 71,)
• NCBI Gene ID: 10817
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJJ7
  UNIPROT ID#>>O43559
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

fibroblast growth factor receptor substrate 3 interacts with:

• ADAMTS like 4
  anaphase promoting complex subunit 11
  ankyrin repeat domain 55
  ATP23 metallopeptidase and ATP synthase assembly factor homolog
  cation channel sperm associated 1
  CD2 associated protein
  chibby family member 2
  chromosome 11 open reading frame 1
  chromosome 19 open reading frame 54
  chromosome 22 open reading frame 39
  coiled-coil domain containing 33
  cysteine rich DPF motif domain containing 1
  cysteine rich tail 1
  doublecortin domain containing 2B
  doublesex and mab-3 related transcription factor 3
  DPEP2 neighbor
  endothelial cell specific molecule 1
  fibroblast growth factor receptor substrate 3
  IKAROS family zinc finger 3
  inhibitor of CDK, cyclin A1 interacting protein 1
  ISY1-RAB43 readthrough
  katanin regulatory subunit B1 like 1
  keratin 76
  keratin associated protein 10-8
  keratin associated protein 1-1
  keratin associated protein 11-1
  keratin associated protein 3-1
  keratin associated protein 3-2
  keratin associated protein 6-2
  keratinocyte proline rich protein
  leucine rich repeat and Ig domain containing 1
  leucine rich repeat containing 18
  methyl-CpG binding domain protein 3 like 1
  migration and invasion inhibitory protein
  NAD synthetase 1
  NBPF member 19
  notch 2 N-terminal like A
  phospholipase B1
  PIH1 domain containing 2
  plasmolipin
  POF1B actin binding protein
  PR/SET domain 6
  protein phosphatase 1 regulatory subunit 32
  regulatory factor X6
  Rho family GTPase 1
  RIMS binding protein 3C
  saitohin
  SH2B adaptor protein 1
  SH3 domain containing kinase binding protein 1
  SLAIN motif family member 1
  sodium channel modifier 1
  spermatogenesis associated 12
  suppressor of cytokine signaling 4
  t-complex 10 like
  testis specific 10 interacting protein
  transglutaminase 7
  unk like zinc finger
  vestigial like family member 3
  WD repeat domain 83
  WW domain containing oxidoreductase
  yippee like 3
  zinc finger and SCAN domain containing 30
  zinc finger MIZ-type containing 2
  zinc finger protein 417
  zinc finger protein 438
  zinc finger protein 446
  zinc finger protein 552

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.