RASSF1, Ras association domain family member 1

RASSF1, Ras association domain family member 1

• This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]

• Gene Synonyms (ras association domain-containing protein 1, Ras association (RalGDS/AF-6) domain family member 1, WUGSC:H_LUCA12.5, cardiac-specific ras association domain family 1 protein, pancreas-specific ras association domain family 1 protein, tumor suppressor protein RDA32, 123F2, NORE2A, RASSF1A, RDA32, REH3P21,)
• NCBI Gene ID: 11186
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NS23
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Ras association domain family member 1 interacts with:

• ATPase, Ca++ transporting, plasma membrane 4
  chromosome 7 open reading frame 25
  chromosome 8 open reading frame 33
  cytokine dependent hematopoietic cell linker
  exosome component 8
  exportin 6
  F-box and WD repeat domain containing 11
  fizzy and cell division cycle 20 related 1
  GLIS family zinc finger 2
  H2A clustered histone 21
  inositol 1,4,5-trisphosphate receptor interacting protein
  itchy E3 ubiquitin protein ligase
  large tumor suppressor kinase 2
  lysine demethylase 1A
  microtubule associated protein 1S
  microtubule associated serine/threonine kinase 2
  modulator of apoptosis 1
  nudix hydrolase 10
  Ras association (RalGDS/AF-6) domain family member 1
  Ras association domain family member 1
  Ras association domain family member 5
  ras homolog family member U
  salvador family WW domain containing protein 1
  SMAD specific E3 ubiquitin protein ligase 1
  sorting nexin 27
  suppressor of variegation 3-9 homolog 2
  tubulin beta class I

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.