HOGA1, 4-hydroxy-2-oxoglutarate aldolase 1

HOGA1, 4-hydroxy-2-oxoglutarate aldolase 1

• The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]

• Gene Synonyms (C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase, mitochondrial, DHDPS-like protein, N-acetylneuraminate pyruvate lyase 2 (putative), dihydrodipicolinate synthase-like, mitochondrial, dihydrodipicolinate synthetase homolog 2, probable 2-keto-4-hydroxyglutarate aldolase, probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial, probable KHG-aldolase, protein 569272,)
• NCBI Gene ID: 112817
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q86XE5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

4-hydroxy-2-oxoglutarate aldolase 1 interacts with:

• 4-hydroxy-2-oxoglutarate aldolase 1
  aarF domain containing kinase 5
  outer dense fiber of sperm tails 3
  SPRY domain containing 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.