PRICKLE1, prickle planar cell polarity protein 1

PRICKLE1, prickle planar cell polarity protein 1

• This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]

• Gene Synonyms (EPM1B, RILP, prickle-like protein 1, REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein, REST/NRSF interacting LIM domain protein, REST/NRSF-interacting LIM domain protein 1, prickle homolog 1, prickle-like 1,)
• NCBI Gene ID: 144165
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KVG3
  UNIPROT ID#>>B3KVG6
  UNIPROT ID#>>Q96MT3
  UNIPROT ID#>>A0A024R0W7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prickle planar cell polarity protein 1 interacts with:

• prickle planar cell polarity protein 1
  Ras association domain family member 10

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.