PUF60, poly(U) binding splicing factor 60

PUF60, poly(U) binding splicing factor 60

• This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

• Gene Synonyms (FIR, RoBPI, SIAHBP1, VRJS, poly(U)-binding-splicing factor PUF60, FBP interacting repressor, FUSE-binding protein-interacting repressor, Ro ribonucleoprotein-binding protein 1, Siah binding protein 1, poly(U) binding splicing factor 60KDa, pyrimidine tract binding splicing factor,)
• NCBI Gene ID: 22827
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHX1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

poly(U) binding splicing factor 60 interacts with:

• AAR2 splicing factor
  ADP ribosylation factor like GTPase 8A
  arginine and glutamate rich 1
  BLOC-1 related complex subunit 5
  bromodomain containing 7
  cereblon
  cullin associated and neddylation dissociated 1
  cytoplasmic polyadenylation element binding protein 2
  DNA damage inducible transcript 4 like
  elaC ribonuclease Z 2
  F-box and WD repeat domain containing 7
  F-box protein 7
  ferritin heavy chain like 17
  forkhead box Q1
  glutamine rich 1
  heterogeneous nuclear ribonucleoprotein A3
  INO80 complex subunit B
  integrin alpha FG-GAP repeat containing 1
  IQ motif containing N
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  KH domain containing 4, pre-mRNA splicing factor
  kinesin light chain 4
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  mediator complex subunit 28
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 3
  mitochondrial rRNA methyltransferase 3
  myosin XVIIIA
  niban apoptosis regulator 2
  Obg like ATPase 1
  obscurin like cytoskeletal adaptor 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(rC) binding protein 3
  poly(U) binding splicing factor 60
  polypyrimidine tract binding protein 2
  pre-mRNA processing factor 40 homolog A
  protein phosphatase 1 regulatory subunit 16A
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  RNA binding motif protein 25
  SAP30 binding protein
  serine/arginine repetitive matrix 2
  seryl-tRNA synthetase 2, mitochondrial
  sirtuin 7
  SNW domain containing 1
  splicing factor 3b subunit 1
  splicing factor 3b subunit 6
  splicing regulatory glutamic acid and lysine rich protein 1
  tectonin beta-propeller repeat containing 2
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin-conjugating enzyme E2K
  UPF2 regulator of nonsense mediated mRNA decay
  upstream binding transcription factor like 1
  VPS29 retromer complex component
  zinc finger protein 746
  zymogen granule protein 16

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.