STK36, serine/threonine kinase 36

STK36, serine/threonine kinase 36

• This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

• Gene Synonyms (serine/threonine-protein kinase 36, fused homolog, testicular tissue protein Li 188, FU,)
• NCBI Gene ID: 27148
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJW1
  UNIPROT ID#>>Q9NRP7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serine/threonine kinase 36 interacts with:

• armadillo repeat containing 6
  CDK5 regulatory subunit associated protein 2
  cytokine dependent hematopoietic cell linker
  ETAA1 activator of ATR kinase
  serine/threonine kinase 36
  SUFU negative regulator of hedgehog signaling

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.