HTRA2, HtrA serine peptidase 2

HTRA2, HtrA serine peptidase 2

• This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

• Gene Synonyms (serine protease HTRA2, mitochondrial, HtrA-like serine protease, Omi stress-regulated endoprotease, epididymis secretory sperm binding protein, high temperature requirement protein A2, protease, serine, 25, serine protease 25, serine proteinase OMI, MGCA8, OMI, PARK13, PRSS25,)
• NCBI Gene ID: 27429
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43464
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

HtrA serine peptidase 2 interacts with:

• 4-hydroxyphenylpyruvate dioxygenase like
  abhydrolase domain containing 10, depalmitoylase
  baculoviral IAP repeat containing 6
  baculoviral IAP repeat containing 7
  cell cycle and apoptosis regulator 2
  cutA divalent cation tolerance homolog
  diablo IAP-binding mitochondrial protein
  HtrA serine peptidase 2
  mitochondrial E3 ubiquitin protein ligase 1
  mitochondrial ribosomal protein L4
  NAD kinase 2, mitochondrial
  NADH:ubiquinone oxidoreductase complex assembly factor 4
  N-terminal glutamine amidase 1
  p21 (RAC1) activated kinase 5
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  pleckstrin homology domain containing A4
  PTEN induced kinase 1
  RAN binding protein 10
  required for meiotic nuclear division 5 homolog A
  TNFAIP3 interacting protein 2
  tubulin beta 6 class V
  tubulin beta class I
  WD repeat domain 26

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.