IGFBP1, insulin like growth factor binding protein 1

IGFBP1, insulin like growth factor binding protein 1

• This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]

• Gene Synonyms (insulin-like growth factor-binding protein 1, IBP-1, IGF-binding protein 1, IGFBP-1, alpha-pregnancy-associated endometrial globulin, amniotic fluid binding protein, binding protein-25, binding protein-26, binding protein-28, growth hormone independent-binding protein, placental protein 12, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1,)
• NCBI Gene ID: 3484
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P08833
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin like growth factor binding protein 1 interacts with:

• ADAM metallopeptidase with thrombospondin type 1 motif 1
  GTP binding protein 2
  lipase maturation factor 2
  matrix metallopeptidase 26
  N-deacetylase and N-sulfotransferase 2
  plasminogen activator, tissue type
  plexin domain containing 2
  protein tyrosine phosphatase non-receptor type 3
  SPARC related modular calcium binding 1
  sushi domain containing 5
  thyroid hormone receptor interactor 6
  TIMP metallopeptidase inhibitor 1
  TIMP metallopeptidase inhibitor 3
  transferrin
  ubiquitin specific peptidase 46
  zinc finger protein 664
  zinc finger protein 696

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.