HERC5, HECT and RLD domain containing E3 ubiquitin protein ligase 5

HERC5, HECT and RLD domain containing E3 ubiquitin protein ligase 5

• This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ISG15--protein ligase HERC5, HECT domain and RCC1-like domain-containing protein 5, cyclin-E-binding protein 1, hect domain and RLD 5, probable E3 ubiquitin-protein ligase HERC5, CEB1, CEBP1,)
• NCBI Gene ID: 51191
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DXV3
  UNIPROT ID#>>Q9UII4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

HECT and RLD domain containing E3 ubiquitin protein ligase 5 interacts with:

• cyclic GMP-AMP synthase
  DGCR8 microprocessor complex subunit
  family with sequence similarity 234 member B
  G-patch domain containing 4
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  histone H3 associated protein kinase
  metadherin
  metastasis associated 1
  NOP16 nucleolar protein
  nuclear receptor interacting protein 3
  nuclear RNA export factor 2
  pyrin and HIN domain family member 1
  ribosome binding protein 1
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  signal recognition particle 72
  sirtuin 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.