FBXL12, F-box and leucine rich repeat protein 12

FBXL12, F-box and leucine rich repeat protein 12

• Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (F-box/LRR-repeat protein 12, F-box protein FBL12, Fbl12,)
• NCBI Gene ID: 54850
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NXK8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

F-box and leucine rich repeat protein 12 interacts with:

• COBW domain containing 3
  dedicator of cytokinesis 8
  egl-9 family hypoxia inducible factor 3
  Fas binding factor 1
  F-box and leucine rich repeat protein 12
  ligand of numb-protein X 1
  ring finger protein 32
  tetratricopeptide repeat domain 27
  TNFAIP3 interacting protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.