PAK6, p21 (RAC1) activated kinase 6

PAK6, p21 (RAC1) activated kinase 6

• This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

• Gene Synonyms (PAK5, serine/threonine-protein kinase PAK 6, p21 protein (Cdc42/Rac)-activated kinase 6, p21(CDKN1A)-activated kinase 6,)
• NCBI Gene ID: 56924
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R9Q4
  UNIPROT ID#>>Q9NQU5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

p21 (RAC1) activated kinase 6 interacts with:

• leucine rich repeat kinase 1
  leucine rich repeat kinase 2
  ligand of numb-protein X 1
  p21 (RAC1) activated kinase 6
  ras homolog family member J
  ras homolog family member V

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.