- Gene Overview
- Interaction Network
- Sequence Verification
PSMB10, proteasome 20S subunit beta 10
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]
-
Gene Synonyms (proteasome subunit beta type-10, low molecular mass protein 10, macropain subunit MECl-1, multicatalytic endopeptidase complex subunit MECl-1, proteasome (prosome, macropain) subunit, beta type, 10, proteasome MECl-1, proteasome catalytic subunit 2i, proteasome subunit MECL1, proteasome subunit beta 10, proteasome subunit beta 7i, proteasome subunit beta-2i, proteasome subunit beta2i, LMP10, MECL1, beta2i,)
- NCBI Gene ID:
5699
- Species:
Homo sapiens (Human)
-
UNIPROT ID#>>P40306
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
proteasome 20S subunit beta 10 interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
|