PTPN2, protein tyrosine phosphatase non-receptor type 2

PTPN2, protein tyrosine phosphatase non-receptor type 2

• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

• Gene Synonyms (tyrosine-protein phosphatase non-receptor type 2, T-cell protein tyrosine phosphatase, PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP,)
• NCBI Gene ID: 5771
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K3N4
  UNIPROT ID#>>K7EQG9
  UNIPROT ID#>>Q59F91
  UNIPROT ID#>>D3DUJ3
  UNIPROT ID#>>P17706
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein tyrosine phosphatase non-receptor type 2 interacts with:

• acidic nuclear phosphoprotein 32 family member B
  acidic nuclear phosphoprotein 32 family member C
  acidic nuclear phosphoprotein 32 family member E
  adenosylhomocysteinase like 1
  adhesion regulating molecule 1
  ankyrin repeat domain 52
  BAG cochaperone 3
  beta-1,4-glucuronyltransferase 1
  biogenesis of ribosomes BRX1
  CASK interacting protein 1
  chondroitin sulfate proteoglycan 5
  chromosome 8 open reading frame 33
  complement component 5a receptor 2
  coronin 1C
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DnaJ heat shock protein family (Hsp40) member C10
  dual specificity phosphatase 10
  eEF1A lysine and N-terminal methyltransferase
  exosome component 4
  family with sequence similarity 220 member A
  FtsJ RNA 2'-O-methyltransferase 3
  G3BP stress granule assembly factor 1
  GADD45G interacting protein 1
  GAR1 ribonucleoprotein
  golgi integral membrane protein 4
  golgi membrane protein 2
  GTP binding protein 10
  high mobility group nucleosome binding domain 5
  karyopherin subunit alpha 6
  katanin regulatory subunit B1
  leucine rich pentatricopeptide repeat containing
  mitochondrial rRNA methyltransferase 3
  nicotinamide nucleotide adenylyltransferase 1
  NOP2/Sun RNA methyltransferase 5
  nucleoporin 153
  nucleoporin 50
  occludin
  OTU deubiquitinase with linear linkage specificity like
  partner of NOB1 homolog
  pleckstrin homology domain containing A4
  proteasomal ATPase associated factor 1
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 6
  protein tyrosine phosphatase non-receptor type 20
  protein tyrosine phosphatase non-receptor type 6
  PSMC3 interacting protein
  ribonuclease P/MRP subunit p30
  ribosomal protein L3 like
  RNA binding motif protein 34
  RNA terminal phosphate cyclase like 1
  SET domain containing 7, histone lysine methyltransferase
  SHC adaptor protein 1
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  signal transducer and activator of transcription 6
  solute carrier family 39 member 4
  solute carrier family 39 member 5
  SRC proto-oncogene, non-receptor tyrosine kinase
  syntaxin 17
  tectonic family member 2
  thioredoxin domain containing 5
  thioredoxin like 1
  TNF receptor associated factor 2
  transcription factor B1, mitochondrial
  transmembrane p24 trafficking protein 10
  transmembrane p24 trafficking protein 9
  transmembrane protein 17
  transmembrane protein 216
  tripartite motif containing 28
  tRNA methyltransferase 61B
  tropomodulin 3
  tropomyosin 4
  ubiquitin C
  ubiquitin C-terminal hydrolase L5
  ubiquitin protein ligase E3A
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 47
  valyl-tRNA synthetase 1
  zinc finger CCCH-type containing, antiviral 1 like

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.