LRPPRC, leucine rich pentatricopeptide repeat containing

LRPPRC, leucine rich pentatricopeptide repeat containing

• This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]

• Gene Synonyms (leucine-rich PPR motif-containing protein, mitochondrial, 130 kDa leucine-rich protein, LRP 130, leucine-rich PPR-motif containing, mitochondrial leucine-rich PPR motif-containing protein, CLONE-23970, GP130, LRP130, LSFC,)
• NCBI Gene ID: 10128
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P42704
  UNIPROT ID#>>E5KNY5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leucine rich pentatricopeptide repeat containing interacts with:

• AAR2 splicing factor
  aldehyde dehydrogenase 16 family member A1
  aminoadipate-semialdehyde synthase
  ankyrin repeat and SOCS box containing 5
  anterior gradient 2, protein disulphide isomerase family member
  armadillo repeat containing X-linked 3
  aurora kinase A interacting protein 1
  autophagy related 101
  B cell receptor associated protein 31
  bromodomain containing 7
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  BUB1, mitotic checkpoint serine/threonine kinase
  cadherin 1
  CECR2 histone acetyl-lysine reader
  centrosomal protein 250
  centrosomal protein 76
  coiled-coil domain containing 8
  coronin 1C
  cytochrome c oxidase assembly factor 3
  dual specificity phosphatase 13
  dual specificity phosphatase 14
  dual specificity phosphatase 15
  dual specificity phosphatase 21
  dual specificity phosphatase 23
  dual specificity phosphatase 26
  dual specificity phosphatase 28
  egl-9 family hypoxia inducible factor 3
  ER degradation enhancing alpha-mannosidase like protein 3
  ER membrane protein complex subunit 4
  ER membrane protein complex subunit 8
  eukaryotic translation initiation factor 2 alpha kinase 4
  F-box and WD repeat domain containing 11
  F-box protein 25
  F-box protein 6
  GABA type A receptor associated protein like 2
  glutamate rich WD repeat containing 1
  glutathione S-transferase kappa 1
  HAUS augmin like complex subunit 2
  heme binding protein 2
  HEXIM P-TEFb complex subunit 1
  influenza virus NS1A binding protein
  lactamase beta
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat containing 59
  leucine rich repeat containing G protein-coupled receptor 4
  leucyl-tRNA synthetase 1
  limb development membrane protein 1 like
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 22
  mex-3 RNA binding family member C
  microtubule associated protein 1S
  MINDY lysine 48 deubiquitinase 4
  mitochondrial contact site and cristae organizing system subunit 10
  mitochondrial ribosomal protein S35
  mitochondrial rRNA methyltransferase 1
  NADH:ubiquinone oxidoreductase core subunit S7
  N-alpha-acetyltransferase 38, NatC auxiliary subunit
  nicotinamide nucleotide transhydrogenase
  NIMA related kinase 6
  nuclear RNA export factor 1
  peptidylprolyl isomerase E
  phosphatase and actin regulator 3
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pleckstrin homology like domain family A member 3
  potassium channel tetramerisation domain containing 5
  PPARG coactivator 1 alpha
  prolyl-tRNA synthetase 2, mitochondrial
  protein tyrosine phosphatase 4A3
  protein tyrosine phosphatase mitochondrial 1
  PTEN induced kinase 1
  RAB5 interacting factor
  RAD18 E3 ubiquitin protein ligase
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  Sec23 homolog A, COPII coat complex component
  sirtuin 1
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  SPC25 component of NDC80 kinetochore complex
  SprT-like N-terminal domain
  SRA stem-loop interacting RNA binding protein
  staphylococcal nuclease and tudor domain containing 1
  testis expressed 101
  translocase of inner mitochondrial membrane domain containing 1
  translocase of outer mitochondrial membrane 40
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  transmembrane protein 41B
  tRNA methyltransferase 61B
  ubiquilin 2
  ubiquitin specific peptidase 19
  ubiquitin specific peptidase 49
  unc-93 homolog B1, TLR signaling regulator
  vesicle associated membrane protein 5
  vir like m6A methyltransferase associated
  WD repeat containing, antisense to TP73
  WD repeat domain 76
  zinc finger CCCH-type containing 14
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.