CLEC7A, C-type lectin domain containing 7A

CLEC7A, C-type lectin domain containing 7A

• This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

• Gene Synonyms (C-type lectin domain family 7 member A, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12, C-type lectin superfamily member 12, DC-associated C-type lectin 1, beta-glucan receptor, dectin-1, dendritic cell-associated C-type lectin-1, lectin-like receptor 1, BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2,)
• NCBI Gene ID: 64581
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q68D78
  UNIPROT ID#>>Q9BXN2
  UNIPROT ID#>>A0A0S2Z5Q1
  UNIPROT ID#>>A0A024RAN9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-type lectin domain containing 7A interacts with:

• ADAM metallopeptidase domain 33
  ADP ribosylation factor like GTPase 13B
  chromosome 14 open reading frame 180
  cortexin 3
  C-type lectin domain containing 7A
  fibronectin type III domain containing 9
  jagunal homolog 1
  mitochondrial translational initiation factor 3
  occludin
  small integral membrane protein 3
  spectrin repeat containing nuclear envelope family member 4
  sushi domain containing 3
  testis expressed 29
  TLC domain containing 4
  transmembrane protein 79

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