PDIA2, protein disulfide isomerase family A member 2

PDIA2, protein disulfide isomerase family A member 2

• This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]

• Gene Synonyms (protein disulfide-isomerase A2, Rho GDP dissociation inhibitor gamma, pancreas-specific protein disulfide isomerase, pancreatic protein disulfide isomerase, protein disulfide isomerase, pancreatic, protein disulfide isomerase-associated 2, PDA2, PDI, PDIP, PDIR,)
• NCBI Gene ID: 64714
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13087
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein disulfide isomerase family A member 2 interacts with:

• histocompatibility minor 13
  keratin associated protein 12-1
  keratin associated protein 6-1
  prolyl 4-hydroxylase subunit alpha 3
  synoviolin 1

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