TARBP2, TARBP2 subunit of RISC loading complex

TARBP2, TARBP2 subunit of RISC loading complex

• HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (RISC-loading complex subunit TARBP2, TAR (HIV) RNA-binding protein 2, TAR (HIV) RNA-binding protein TRBP1, TAR (HIV-1) RNA binding protein 2, TAR RNA binding protein 2, TARBP2, RISC loading complex RNA binding subunit, trans-activation responsive RNA-binding protein, LOQS, TRBP, TRBP1, TRBP2,)
• NCBI Gene ID: 6895
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15633
  UNIPROT ID#>>A0A024RB49
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TARBP2 subunit of RISC loading complex interacts with:

• ADAM metallopeptidase with thrombospondin type 1 motif 4
  A-kinase anchoring protein 17A
  argonaute RISC catalytic component 2
  argonaute RISC catalytic component 3
  argonaute RISC component 1
  carboxypeptidase A6
  CCAAT enhancer binding protein zeta
  chromosome 1 open reading frame 35
  cilia and flagella associated protein 20
  cullin 3
  DEAD-box helicase 27
  DExD-box helicase 50
  dicer 1, ribonuclease III
  dicer 1, ribonuclease type III
  DNA topoisomerase I
  egl-9 family hypoxia inducible factor 3
  forkhead box D4 like 6
  G-patch domain containing 4
  haloacid dehalogenase like hydrolase domain containing 2
  heterochromatin protein 1 binding protein 3
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  mastermind like transcriptional coactivator 1
  mediator complex subunit 21
  mediator of cell motility 1
  mitogen-activated protein kinase 8 interacting protein 2
  NEDD4 like E3 ubiquitin protein ligase
  NOC3 like DNA replication regulator
  nuclear RNA export factor 1
  nudix hydrolase 18
  peter pan homolog
  PNKD metallo-beta-lactamase domain containing
  polynucleotide kinase 3'-phosphatase
  POP1 homolog, ribonuclease P/MRP subunit
  potassium voltage-gated channel interacting protein 3
  protein activator of interferon induced protein kinase EIF2AK2
  protein tyrosine phosphatase 4A2
  RecQ like helicase 4
  Rho GTPase activating protein 36
  ribosomal RNA processing 12 homolog
  ribosomal RNA processing 1B
  ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
  ribosome binding protein 1
  RNA binding motif protein 14
  RNA binding motif protein 28
  RNA binding motif protein 4B
  SDA1 domain containing 1
  sideroflexin 3
  spermatid perinuclear RNA binding protein
  TARBP2 subunit of RISC loading complex
  TGFB induced factor homeobox 2
  TNF receptor associated factor 4
  TNF receptor associated factor 6
  transcription elongation factor A N-terminal and central domain containing
  transcription elongation factor A2
  treacle ribosome biogenesis factor 1
  tripartite motif containing 41
  tRNA methyltransferase 1
  tRNA methyltransferase 2 homolog A
  TSR1 ribosome maturation factor
  vav guanine nucleotide exchange factor 2
  WD repeat domain 46
  zinc finger matrin-type 3
  zinc finger matrin-type 4
  zinc finger protein 346
  zinc finger protein 669

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.