TDO2, tryptophan 2,3-dioxygenase

TDO2, tryptophan 2,3-dioxygenase

• This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

• Gene Synonyms (tryptophan 2,3-dioxygenase, tryptamin 2,3-dioxygenase, tryptophan oxygenase, tryptophan pyrrolase, tryptophanase, HYPTRP, TDO, TO, TPH2, TRPO,)
• NCBI Gene ID: 6999
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P48775
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tryptophan 2,3-dioxygenase interacts with:

• acetylserotonin O-methyltransferase like
  dolichyl-phosphate mannosyltransferase subunit 1, catalytic
  ligand of numb-protein X 1
  lysine demethylase 1A
  MOB kinase activator 1A
  MOB kinase activator 3C
  neuroglobin
  nicotinamide nucleotide adenylyltransferase 1
  nuclear receptor subfamily 1 group D member 1
  peptidase M20 domain containing 2
  protein arginine methyltransferase 6
  protein interacting with PRKCA 1
  syndecan binding protein 2
  tryptophan 2,3-dioxygenase
  zinc finger FYVE-type containing 26

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.