TNXB, tenascin XB

TNXB, tenascin XB

• This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tenascin-X, growth-inhibiting protein 45, hexabrachion-like protein, tenascin XB1, tenascin XB2, EDS3, EDSCLL, EDSCLL1, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS,)
• NCBI Gene ID: 7148
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95680
  UNIPROT ID#>>Q9Y464
  UNIPROT ID#>>Q6IPK3
  UNIPROT ID#>>P22105
  UNIPROT ID#>>O95681
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tenascin XB interacts with:

• BTG3 associated nuclear protein
  fidgetin like 1
  POU class 6 homeobox 2
  transglutaminase 7
  vascular endothelial growth factor A
  vascular endothelial growth factor B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.