XRCC1, X-ray repair cross complementing 1

XRCC1, X-ray repair cross complementing 1

• The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DNA repair protein XRCC1, X-ray repair complementing defective repair in Chinese hamster cells 1, X-ray repair cross-complementing protein 1, RCC, SCAR26,)
• NCBI Gene ID: 7515
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P18887
  UNIPROT ID#>>B2RCY5
  UNIPROT ID#>>Q59HH7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

X-ray repair cross complementing 1 interacts with:

• ADP ribosylation factor like GTPase 6 interacting protein 5
  apoptosis inducing factor mitochondria associated 1
  aprataxin
  aprataxin and PNKP like factor
  beta-transducin repeat containing E3 ubiquitin protein ligase
  bromodomain and PHD finger containing 1
  cell division cycle 14B
  cereblon
  chromodomain helicase DNA binding protein 1 like
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 2 associated protein 1
  diphthamide biosynthesis 7
  DNA polymerase iota
  DNA polymerase kappa
  embryonic ectoderm development
  exportin for tRNA
  forkhead box B1
  forkhead box D3
  forkhead box P1
  GRIP and coiled-coil domain containing 1
  GTF2I repeat domain containing 1
  H2A clustered histone 4
  H2B clustered histone 1
  H2B clustered histone 8
  H3 clustered histone 1
  H4 clustered histone 1
  jun B proto-oncogene
  mab-21 like 2
  mitogen-activated protein kinase kinase kinase 20
  nei like DNA glycosylase 1
  non-SMC condensin I complex subunit G
  pellino E3 ubiquitin protein ligase 1
  peptidylprolyl isomerase H
  pleckstrin homology domain containing A4
  poly(ADP-ribose) polymerase 2
  polynucleotide kinase 3'-phosphatase
  protein kinase C, iota
  protocadherin beta 11
  PTPRF interacting protein alpha 1
  ring finger protein 146
  ring finger protein 166
  RNA pseudouridine synthase D4
  S100 calcium binding protein A16
  SEC22 homolog B, vesicle trafficking protein
  septin 11
  single stranded DNA binding protein 3
  sirtuin 1
  solute carrier family 39 member 10
  splicing factor 3b subunit 6
  timeless circadian regulator
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TPX2, microtubule-associated
  ubiquitin associated protein 2 like
  X-ray repair cross complementing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.