FBXO11, F-box protein 11

FBXO11, F-box protein 11

• This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

• Gene Synonyms (F-box only protein 11, protein arginine N-methyltransferase 9, ubiquitin protein ligase E3 component n-recognin 6, vitiligo-associated protein 1, vitiligo-associated protein VIT-1, FBX11, IDDFBA, PRMT9, UBR6, UG063H01, VIT1,)
• NCBI Gene ID: 80204
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q86XK2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

F-box protein 11 interacts with:

• coiled-coil domain containing 107
  F-box protein 11
  heat shock protein family B (small) member 6
  kirre like nephrin family adhesion molecule 2
  ligand of numb-protein X 1
  myosin light chain kinase 2
  Scm polycomb group protein like 4
  t-complex 10 like
  THAP domain containing 7
  unk zinc finger
  zinc and ring finger 4
  zinc finger protein 785

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.