MKNK1, MAPK interacting serine/threonine kinase 1

MKNK1, MAPK interacting serine/threonine kinase 1

• This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

• Gene Synonyms (MAP kinase-interacting serine/threonine-protein kinase 1, MAP kinase interacting serine/threonine kinase 1, MAP kinase signal-integrating kinase 1, MAPK signal-integrating kinase 1, MNK1,)
• NCBI Gene ID: 8569
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BUB5
  UNIPROT ID#>>A8K341
  UNIPROT ID#>>Q7Z319
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MAPK interacting serine/threonine kinase 1 interacts with:

• biorientation of chromosomes in cell division 1 like 1
  charged multivesicular body protein 4C
  cullin 1
  DENN/MADD domain containing 6A
  dimethylarginine dimethylaminohydrolase 2
  egl-9 family hypoxia inducible factor 3
  eukaryotic translation initiation factor 4 gamma 3
  flotillin 1
  hepatocyte growth factor-regulated tyrosine kinase substrate
  homeodomain interacting protein kinase 2
  intersectin 2
  kinesin family member 18A
  kinesin family member 1C
  MAPK interacting serine/threonine kinase 1
  muskelin 1, intracellular mediator containing kelch motifs
  myosin heavy chain 13
  NIMA (never in mitosis gene a)-related expressed kinase 2
  par-6 family cell polarity regulator beta
  PDZ and LIM domain 5
  phosphorylated adaptor for RNA export
  ras homolog family member A
  reticulocalbin 3
  ribonuclease H2 subunit B
  septin 7
  sprouty RTK signaling antagonist 2
  TNFAIP3 interacting protein 2
  widely-interspaced zinc finger motifs

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.