AKR7A2, aldo-keto reductase family 7 member A2

AKR7A2, aldo-keto reductase family 7 member A2

• The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

• Gene Synonyms (aflatoxin B1 aldehyde reductase member 2, AFB1 aldehyde reductase 1, AFB1-AR 1, HEL-S-166mP, SSA reductase, aflatoxin aldehyde reductase, aflatoxin beta1 aldehyde reductase, aldoketoreductase 7, epididymis secretory sperm binding protein Li 166mP, succinic semialdehyde reductase, AFAR, AFAR1, AFB1-AR1, AKR7,)
• NCBI Gene ID: 8574
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DZX4
  UNIPROT ID#>>O43488
  UNIPROT ID#>>V9HWA2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aldo-keto reductase family 7 member A2 interacts with:

• aldo-keto reductase family 7 member A2
  aldo-keto reductase family 7 member A3
  biorientation of chromosomes in cell division 1 like 1
  centrosomal protein 131
  cilia and flagella associated protein 298
  CTR9 homolog, Paf1/RNA polymerase II complex component
  DET1 and DDB1 associated 1
  dual specificity phosphatase 12
  FANCD2 and FANCI associated nuclease 1
  Fas associated via death domain
  inner membrane protein, mitochondrial
  katanin catalytic subunit A1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  MAP/microtubule affinity regulating kinase 2
  microcephalin 1
  MIS12 kinetochore complex component
  myotubularin related protein 12
  myotubularin related protein 14
  NDC80 kinetochore complex component
  pleckstrin homology domain containing A4
  protein kinase, AMP-activated, alpha 1 catalytic subunit
  protein tyrosine phosphatase non-receptor type 21
  protein tyrosine phosphatase non-receptor type 22
  SLAIN motif family, member 2
  SNW domain containing 1
  striatin, calmodulin binding protein 3
  TNFRSF1A associated via death domain
  TPX2, microtubule-associated
  transformation related protein 53 binding protein 1
  transmembrane p24 trafficking protein 10
  tripartite motif containing 63
  UFM1 specific ligase 1
  zinc finger and BTB domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.