LAMTOR3, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

LAMTOR3, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

• This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

• Gene Synonyms (ragulator complex protein LAMTOR3, MAPK scaffold protein 1, MEK binding partner 1, late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, mitogen-activated protein kinase kinase 1 interacting protein 1, mitogen-activated protein kinase scaffold protein 1, MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3,)
• NCBI Gene ID: 8649
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHA4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 interacts with:

• ADAM metallopeptidase with thrombospondin type 1 motif 10
  apolipoprotein L6
  BLOC-1 related complex subunit 6
  CCAAT enhancer binding protein zeta
  copine 6
  DEAD-box helicase 28
  inhibitor of Bruton tyrosine kinase
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  lysophosphatidylcholine acyltransferase 1
  mesothelin
  methyl-CpG binding domain protein 2
  mitochondrial carrier 1
  mitochondrial contact site and cristae organizing system subunit 13
  mitochondrial ribosomal protein L22
  mitochondrial ribosomal protein L39
  mitochondrial ribosomal protein L43
  mitochondrial ribosomal protein L47
  mitochondrial ribosomal protein L51
  mitochondrial ribosomal protein S35
  mitochondrial ribosomal protein S9
  mitochondrial rRNA methyltransferase 3
  NADH:ubiquinone oxidoreductase subunit B11
  NGG1 interacting factor 3 like 1
  nicotinamide nucleotide transhydrogenase
  nucleoporin 58
  O-sialoglycoprotein endopeptidase
  penta-EF-hand domain containing 1
  peptidyl-tRNA hydrolase 2
  phosphodiesterase 4D interacting protein
  poly(U) binding splicing factor 60
  proline rich 3
  RAB14, member RAS oncogene family
  RAB21, member RAS oncogene family
  RAB31, member RAS oncogene family
  RAB9A, member RAS oncogene family
  Ras related GTP binding B
  Ras related GTP binding C
  Ras related GTP binding D
  signal peptidase complex subunit 2
  SUFU negative regulator of hedgehog signaling
  transglutaminase 7
  trans-golgi network protein 2
  translocase of outer mitochondrial membrane 22
  translocase of outer mitochondrial membrane 40
  translocase of outer mitochondrial membrane 70
  transmembrane and coiled-coil domains 1
  TSR1 ribosome maturation factor
  ubiquinol-cytochrome c reductase complex III subunit VII
  ubiquitin protein ligase E3 component n-recognin 1
  WD repeat domain 83
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 43
  zinc finger and SCAN domain containing 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.