TNFRSF25, TNF receptor superfamily member 25

TNFRSF25, TNF receptor superfamily member 25

• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tumor necrosis factor receptor superfamily member 25, Guanine nucleotide exchange factor 720, PH domain-containing family G member 5, Pleckstrin homology domain-containing family G member 5, apoptosis inducing receptor, apoptosis-inducing receptor AIR, apoptosis-mediating receptor DR3, apoptosis-mediating receptor TRAMP, death domain receptor 3 soluble form, death receptor beta, lymphocyte-associated receptor of death, protein WSL-1, tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein), APO-3, DDR3, DR3, GEF720, LARD, PLEKHG5, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR,)
• NCBI Gene ID: 8718
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q93038
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor superfamily member 25 interacts with:

• BAG cochaperone 4
  nucleolar protein 3
  receptor interacting serine/threonine kinase 1
  TNF receptor superfamily member 25
  TNF superfamily member 12
  TNF superfamily member 15

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.