SUCLA2, succinate-CoA ligase ADP-forming subunit beta

SUCLA2, succinate-CoA ligase ADP-forming subunit beta

• Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

• Gene Synonyms (succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, ATP-specific succinyl-CoA synthetase subunit beta, ATP-specific succinyl-CoA synthetase, beta subunit, long intergenic non-protein coding RNA 444, mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta, renal carcinoma antigen NY-REN-39, succinate-CoA ligase ADP-forming beta subunit, succinate-CoA ligase beta subunit, succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial, succinyl-CoA synthetase beta-A chain, A-BETA, A-SCS, LINC00444, MTDPS5, SCS-betaA,)
• NCBI Gene ID: 8803
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y4T0
  UNIPROT ID#>>Q9P2R7
  UNIPROT ID#>>E5KS60
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

succinate-CoA ligase ADP-forming subunit beta interacts with:

• 4-hydroxyphenylpyruvate dioxygenase like
  5'-nucleotidase, cytosolic IIIA
  abhydrolase domain containing 10, depalmitoylase
  acid phosphatase 6, lysophosphatidic
  ADP ribosylation factor like GTPase 6 interacting protein 1
  angiotensin II receptor associated protein
  argonaute RISC component 4
  BCL2 like 14
  chromosome 17 open reading frame 80
  CKLF like MARVEL transmembrane domain containing 5
  coenzyme Q9
  developmental pluripotency-associated 3
  DNL-type zinc finger
  egl-9 family hypoxia inducible factor 3
  family with sequence similarity 9 member B
  Fas associated factor family member 2
  FKBP prolyl isomerase 7
  G elongation factor mitochondrial 1
  glyoxylate and hydroxypyruvate reductase
  GrpE like 1, mitochondrial
  GTP binding protein 10
  histidyl-tRNA synthetase 2, mitochondrial
  HtrA serine peptidase 2
  IQ motif containing GTPase activating protein 2
  L3MBTL histone methyl-lysine binding protein 1
  lon peptidase 2, peroxisomal
  mal, T cell differentiation protein 2
  methionyl aminopeptidase 2
  methylcrotonoyl-CoA carboxylase 1
  mitochondrial rRNA methyltransferase 1
  NAD kinase 2, mitochondrial
  NAD(P)HX epimerase
  NFS1 cysteine desulfurase
  NFU1 iron-sulfur cluster scaffold
  nitrilase family member 2
  peptidase, mitochondrial processing subunit alpha
  peptidase, mitochondrial processing subunit beta
  pitrilysin metallopeptidase 1
  pleckstrin homology domain containing A4
  proteasome 26S subunit, non-ATPase 14
  protein O-glucosyltransferase 3
  RNA exonuclease 2
  S100 calcium binding protein A16
  SEC22 homolog B, vesicle trafficking protein
  Sec23 homolog A, COPII coat complex component
  SH3 domain binding glutamate rich protein like 3
  testin LIM domain protein
  testis expressed 101
  transportin 1
  tripartite motif containing 28
  tRNA methyltransferase 61B
  tyrosyl-tRNA synthetase 2
  zinc finger MYND-type containing 19

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.