GMPS, guanine monophosphate synthase

GMPS, guanine monophosphate synthase

• In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

• Gene Synonyms (GMP synthase [glutamine-hydrolyzing], GMP synthase, GMP synthetase, MLL/GMPS fusion protein, glutamine amidotransferase, guanine monophosphate synthetase, guanosine 5'-monophosphate synthase, testicular tissue protein Li 82, GATD7,)
• NCBI Gene ID: 8833
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJK6
  UNIPROT ID#>>P49915
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

guanine monophosphate synthase interacts with:

• 1-acylglycerol-3-phosphate O-acyltransferase 2
  AAR2 splicing factor
  acyl-CoA synthetase family member 2
  argonaute RISC catalytic component 2
  BRISC and BRCA1 A complex member 1
  Coenzyme A synthase
  copper chaperone for superoxide dismutase
  DET1 and DDB1 associated 1
  EF-hand domain family member D2
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  ETHE1 persulfide dioxygenase
  F-box protein 32
  F-box protein 6
  ferredoxin 2
  glutathione S-transferase omega 1
  kinesin family member 7
  lysine demethylase 6B
  magnesium dependent phosphatase 1
  NAD(P)HX epimerase
  neural precursor cell expressed, developmentally down-regulated gene 1
  nitrilase family member 2
  peptidase, mitochondrial processing subunit alpha
  peptidase, mitochondrial processing subunit beta
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  protein kinase AMP-activated non-catalytic subunit gamma 2
  protein phosphatase methylesterase 1
  PTEN induced kinase 1
  pyruvate kinase, muscle
  Rac GTPase-activating protein 1
  RecQ like helicase 4
  ribose 5-phosphate isomerase A
  ring finger protein 123
  sirtuin 7
  small ubiquitin like modifier 4
  sphingosine kinase 1
  transcription elongation factor A like 1
  trinucleotide repeat containing adaptor 6B
  ubiquitin conjugating enzyme E2 M
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 14
  WD repeat domain 48

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.