BMP15, bone morphogenetic protein 15

BMP15, bone morphogenetic protein 15

• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]

• Gene Synonyms (bone morphogenetic protein 15, growth/differentiation factor 9B, GDF9B, ODG2, POF4,)
• NCBI Gene ID: 9210
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95972
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

bone morphogenetic protein 15 interacts with:

• bone morphogenetic protein 15
  DDB1 and CUL4 associated factor 6
  HECT domain E3 ubiquitin protein ligase 1
  protein phosphatase 2 regulatory subunit Bdelta

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.