MAP4K4, mitogen-activated protein kinase kinase kinase kinase 4

MAP4K4, mitogen-activated protein kinase kinase kinase kinase 4

• The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, Ste20 group protein kinase HGK, epididymis secretory protein Li 31, hepatocyte progenitor kinase-like/germinal center kinase-like kinase, nck-interacting kinase, FLH21957, HEL-S-31, HGK, MEKKK4, NIK,)
• NCBI Gene ID: 9448
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z3V5
  UNIPROT ID#>>V9HWH3
  UNIPROT ID#>>O95819
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase kinase 4 interacts with:

• atlastin GTPase 1
  autophagy related 14
  BICD cargo adaptor 2
  CCR4-NOT transcription complex subunit 11
  centriolin
  centrosomal protein 152
  cyclin dependent kinase 12
  DISC1 scaffold protein
  egl-9 family hypoxia inducible factor 3
  FGFR1 oncogene partner 2
  G3BP stress granule assembly factor 1
  HEPACAM family member 2
  hypoxia inducible factor 1 subunit alpha inhibitor
  kinesin family member 26B
  leucine rich repeat kinase 2
  MANSC domain containing 1
  misshapen like kinase 1
  MOB kinase activator 1B
  nanos C2HC-type zinc finger 2
  NME/NM23 family member 7
  obscurin like cytoskeletal adaptor 1
  PAX interacting protein 1
  pleckstrin homology domain containing A4
  RAP2C, member of RAS oncogene family
  solute carrier family 25 member 41
  striatin 3
  TATA-box binding protein like 2
  testis expressed 101
  testis expressed 264, ER-phagy receptor
  transmembrane protein 17
  vir like m6A methyltransferase associated
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.