PTGES, prostaglandin E synthase

PTGES, prostaglandin E synthase

• The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

• Gene Synonyms (prostaglandin E synthase, MGST1-like 1, glutathione S-transferase 1-like 1, microsomal glutathione S-transferase 1-like 1, microsomal prostaglandin E synthase-1, p53-induced apoptosis protein 12, p53-induced gene 12 protein, tumor protein p53 inducible protein 12, MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1,)
• NCBI Gene ID: 9536
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14684
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prostaglandin E synthase interacts with:

• Bet1 golgi vesicular membrane trafficking protein
  chromosome 4 open reading frame 3
  golgi transport 1B
  GTPase, IMAP family member 1
  GTPase, IMAP family member 5
  prostaglandin E synthase
  SEC22 homolog A, vesicle trafficking protein
  single-pass membrane protein with coiled-coil domains 4
  stress associated endoplasmic reticulum protein family member 2
  transmembrane protein 19
  transmembrane protein 222
  transmembrane protein 65
  Yip1 interacting factor homolog A, membrane trafficking protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.