MACROH2A1, macroH2A.1 histone

MACROH2A1, macroH2A.1 histone

• Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

• Gene Synonyms (core histone macro-H2A.1, H2A histone family member Y, histone H2A.y, histone macroH2A1, histone macroH2A1.1, histone macroH2A1.2, medulloblastoma antigen MU-MB-50.205, H2A.y, H2A/y, H2AF12M, H2AFY, MACROH2A1.1, mH2A1, macroH2A1.2,)
• NCBI Gene ID: 9555
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75367
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

macroH2A.1 histone interacts with:

• activity dependent neuroprotector homeobox
  ADNP homeobox 2
  aprataxin and PNKP like factor
  ataxin 1 like
  bromodomain adjacent to zinc finger domain 2A
  CCCTC-binding factor
  chromobox 1
  chromobox 3
  chromobox 5
  chromobox 8
  chromodomain helicase DNA binding protein 8
  cullin 7
  cyclic GMP-AMP synthase
  cyclin dependent kinase 15
  cysteine rich tail 1
  DDB1 and CUL4 associated factor 1
  death inducer-obliterator 1
  decapping enzyme, scavenger
  DNA methyltransferase 1 associated protein 1
  establishment of sister chromatid cohesion N-acetyltransferase 2
  euchromatic histone lysine methyltransferase 2
  family with sequence similarity 133 member A
  forkhead box B1
  GATA zinc finger domain containing 2A
  GATA zinc finger domain containing 2B
  glutamate rich 2
  H2B clustered histone 1
  HDGF like 2
  histone PARylation factor 1
  HMG-box transcription factor 1
  keratin associated protein 10-8
  leucine zipper protein 4
  lysine demethylase 2A
  macroH2A.2 histone
  matrin 3
  methyl-CpG binding domain protein 3
  methyltransferase like 14
  N-alpha-acetyltransferase 40, NatD catalytic subunit
  NKAP domain containing 1
  nuclear receptor binding SET domain protein 3
  nuclear RNA export factor 1
  nucleolar protein 9
  obscurin like cytoskeletal adaptor 1
  PHD finger protein 12
  PHD finger protein 14
  PHD finger protein 8
  pleckstrin homology domain containing A4
  pogo transposable element derived with ZNF domain
  polybromo 1
  PR/SET domain 16
  pre-mRNA processing factor 3
  pyrin and HIN domain family member 1
  RAD18 E3 ubiquitin protein ligase
  remodeling and spacing factor 1
  REST corepressor 1
  ring-box 1
  RIO kinase 1
  RNA binding motif protein 24
  RNA binding motif protein 39
  RNA binding motif protein X-linked
  RuvB like AAA ATPase 2
  SIN3 transcription regulator family member A
  sirtuin 6
  splicing factor 3b subunit 3
  SPT16 homolog, facilitates chromatin remodeling subunit
  SREK1 interacting protein 1
  SUMO specific peptidase 3
  SUZ12 polycomb repressive complex 2 subunit
  TPX2 microtubule nucleation factor
  tripartite motif containing 59
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin specific peptidase 48
  unk zinc finger
  variable charge X-linked 2
  WD repeat domain 18
  WD repeat domain 76
  WD repeat domain 77
  WIZ zinc finger
  Yes1 associated transcriptional regulator
  zinc finger CCHC-type and RNA binding motif containing 1
  zinc finger MYND-type containing 8
  zinc finger protein 428
  zinc finger protein 622

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.