GAB2, GRB2 associated binding protein 2

GAB2, GRB2 associated binding protein 2

• This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

• Gene Synonyms (GRB2-associated-binding protein 2, Grb2-associated binder 2, growth factor receptor bound protein 2-associated protein 2, pp100,)
• NCBI Gene ID: 9846
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UQC2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GRB2 associated binding protein 2 interacts with:

• ankyrin repeat domain 34A
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  chibby family member 1, beta catenin antagonist
  cingulin
  DENN domain containing 1A
  DENN domain containing 4C
  family with sequence similarity 110 member A
  family with sequence similarity 110 member B
  family with sequence similarity 53 member C
  fibroblast growth factor receptor substrate 2
  GRB10 interacting GYF protein 1
  GRB2 associated binding protein 2
  GRB2 related adaptor protein
  kinesin family member 13B
  leucine rich repeat and fibronectin type III domain containing 1
  leucine rich repeat kinase 1
  LIM domain and actin binding 1
  linker for activation of T cells
  MAPK associated protein 1
  microtubule associated serine/threonine kinase 3
  myosin XVB
  NAD kinase
  potassium channel tetramerization domain containing 3
  protein phosphatase, Mg2+/Mn2+ dependent 1H
  RAB3A interacting protein
  serine and arginine rich splicing factor 12
  signal induced proliferation associated 1 like 1
  SLIT-ROBO Rho GTPase activating protein 2
  synapse defective Rho GTPase homolog 1
  testis associated actin remodelling kinase 2
  ubiquitin specific peptidase 21
  vir like m6A methyltransferase associated
  zinc finger and BTB domain containing 21
  zinc finger protein 638

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.